Substitution Type	Trinucleotide	Somatic Mutation Type	Signature 1	Signature 2	Signature 3	Signature 4	Signature 5	Signature 6	Signature 7
C>A	ACA	A[C>A]A	0.011098326	0.000682708	0.022172307	0.0365	0.014941548	0.0017	0.0004
C>A	ACC	A[C>A]C	0.009149341	0.000619107	0.017871675	0.0309	0.008960918	0.0028	0.0005
C>A	ACG	A[C>A]G	0.00149007	9.9279E-05	0.00213834	0.0183	0.002207846	0.0005	0
C>A	ACT	A[C>A]T	0.006233885	0.000323891	0.016265146	0.0243	0.009206905	0.0019	0.0004
C>G	ACA	A[C>G]A	0.001801068	0.000263481	0.024002615	0.0097	0.011671022	0.0013	0
C>G	ACC	A[C>G]C	0.002580909	0.000269866	0.012160304	0.0054	0.007292089	0.0012	0
C>G	ACG	A[C>G]G	0.000592548	0.000219234	0.005275419	0.0031	0.002303839	0	0
C>G	ACT	A[C>G]T	0.002963986	0.000610973	0.023277656	0.0054	0.011696246	0.0018	0.0001
C>T	ACA	A[C>T]A	0.029514533	0.007441557	0.017872171	0.012	0.021839188	0.0312	0
C>T	ACC	A[C>T]C	0.014322747	0.002726312	0.008896034	0.0075	0.012756106	0.0163	0.0197
C>T	ACG	A[C>T]G	0.171646931	0.003322083	0.003572708	0.0028	0.016760177	0.0908	0.0001
C>T	ACT	A[C>T]T	0.012623763	0.003326528	0.014797612	0.0059	0.016477955	0.0149	0.0043
T>A	ATA	A[T>A]A	0.00402152	1.32377E-07	0.008428564	0.0048	0.008902904	0.0006	0.001
T>A	ATC	A[T>A]C	0.002371144	0.00011307	0.007373097	0.0039	0.007399202	0.0033	0.0008
T>A	ATG	A[T>A]G	0.00281091	0.000532929	0.0073573	0.01	0.011508051	0	0.0009
T>A	ATT	A[T>A]T	0.008360909	0.000149111	0.008753939	0.003	0.011193623	0.0053	0.0035
T>C	ATA	A[T>C]A	0.013915773	0.00130351	0.013035709	0.0084	0.035366735	0.0075	0.0005
T>C	ATC	A[T>C]C	0.006274961	0.000425577	0.00918629	0.002	0.013771102	0.0056	0.0001
T>C	ATG	A[T>C]G	0.010137636	0.000575473	0.01171692	0.0081	0.028449052	0.0217	0.0007
T>C	ATT	A[T>C]T	0.009256316	0.001488164	0.016978871	0.0036	0.027302974	0.0023	0.0011
T>G	ATA	A[T>G]A	0.001587636	3.37184E-05	0.002351368	0	0.003462152	0	0
T>G	ATC	A[T>G]C	0.001784091	2.48448E-05	0.001464231	0.0002	0.002246593	0.0017	0
T>G	ATG	A[T>G]G	0.001385831	0.000273454	0.009053778	0.0015	0.005490217	0.0007	0.0009
T>G	ATT	A[T>G]T	0.003158539	0.000217695	0.007030976	0.0002	0.003821227	0.0029	0
C>A	CCA	C[C>A]A	0.00659587	0.000677445	0.018781726	0.0461	0.009674904	0.0101	0.0012
C>A	CCC	C[C>A]C	0.007342368	0.000213681	0.015760458	0.0614	0.004952301	0.0241	0.0006
C>A	CCG	C[C>A]G	0.00089284	6.77046E-06	0.00196339	0.0088	0.002800627	0.0091	0
C>A	CCT	C[C>A]T	0.007186582	0.000416333	0.014722861	0.0432	0.011013466	0.0571	0.0013
C>G	CCA	C[C>G]A	0.001284983	2.77721E-05	0.016832572	0.0105	0.007537523	0	0.0001
C>G	CCC	C[C>G]C	0.000702135	0.000279644	0.013531442	0.0097	0.007633227	0	0.0004
C>G	CCG	C[C>G]G	0.00050629	1.91616E-05	0.004176458	0.0063	0.00261376	0	0.0006
C>G	CCT	C[C>G]T	0.001381543	0.000312782	0.02404639	0.0094	0.009417098	0.0002	0.0003
C>T	CCA	C[C>T]A	0.020896447	0.015019507	0.014395059	0.021	0.022769209	0.0085	0.0754
C>T	CCC	C[C>T]C	0.018501705	0.003516918	0.008544781	0.0144	0.017509476	0.0099	0.1007
C>T	CCG	C[C>T]G	0.095577217	0.004979276	0.003518466	0.0076	0.012862238	0.0901	0.0208
C>T	CCT	C[C>T]T	0.017113308	0.008956553	0.016075546	0.0201	0.020429513	0.0087	0.0788
T>A	CTA	C[T>A]A	0.001182587	0.000154599	0.00757132	0.0075	0.005043164	0.0001	0
T>A	CTC	C[T>A]C	0.001903167	0.000464019	0.012725464	0.0111	0.006208844	0.0026	0.0014
T>A	CTG	C[T>A]G	0.001487961	0.00023041	0.011508562	0.0342	0.010507569	0.0008	0.0007
T>A	CTT	C[T>A]T	0.002179344	0.000574886	0.016456178	0.0115	0.009784641	0.0011	0.0018
T>C	CTA	C[T>C]A	0.004176675	0.000546619	0.007895013	0.0052	0.01423863	0.0062	0.001
T>C	CTC	C[T>C]C	0.005252593	0.000392333	0.01443117	0.0026	0.0124895	0.004	0.0008
T>C	CTG	C[T>C]G	0.007013225	0.000362025	0.008422972	0.01	0.018741631	0.027	0.001
T>C	CTT	C[T>C]T	0.006713813	0.0005609	0.01193243	0.0054	0.019054083	0.0033	0.0045
T>G	CTA	C[T>G]A	0.000302691	0.000113785	0.001974181	0	0.002041649	0.0001	0
T>G	CTC	C[T>G]C	0.002098502	2.20951E-05	0.005824296	0.0013	0.003478502	0.004	0.0008
T>G	CTG	C[T>G]G	0.001599549	0.000228246	0.010464655	0.0046	0.007147456	0.005	0.0009
T>G	CTT	C[T>G]T	0.002758538	6.71113E-05	0.008724387	0.0012	0.011486812	0.0086	0.0013
C>A	GCA	G[C>A]A	0.008232604	0.000352013	0.00969654	0.0376	0.011892169	0.0024	0.0003
C>A	GCC	G[C>A]C	0.005758021	0.000133817	0.010843341	0.0399	0.009247857	0.0058	0.0001
C>A	GCG	G[C>A]G	0.000616335	0.000178442	0.000929141	0.0227	0.002809188	0.0021	0
C>A	GCT	G[C>A]T	0.00445908	0.000122832	0.012215383	0.0258	0.010301267	0.0087	0.0001
C>G	GCA	G[C>G]A	0.000602123	4.48385E-05	0.011916845	0.007	0.005559423	0	0
C>G	GCC	G[C>G]C	0.002393352	1.45201E-05	0.009823653	0.0091	0.005388801	0.003	0.0004
C>G	GCG	G[C>G]G	2.48534E-07	4.06659E-05	0.001671054	0.0062	0.00110059	0	0
C>G	GCT	G[C>G]T	0.000890081	0.000268429	0.017914334	0.006	0.006041248	0.0017	0
C>T	GCA	G[C>T]A	0.024943814	0.006390808	0.016127273	0.0087	0.020038259	0.0653	0
C>T	GCC	G[C>T]C	0.027161494	0.001995817	0.008208632	0.008	0.018022312	0.0773	0.021
C>T	GCG	G[C>T]G	0.103570762	0.000303021	0.001212923	0.0023	0.013193818	0.1339	0.0002
C>T	GCT	G[C>T]T	0.017689854	0.003265818	0.010611649	0.0082	0.019502915	0.0524	0.0161
T>A	GTA	G[T>A]A	0.000689289	0.000114994	0.004434783	0.0069	0.006740388	0	0
T>A	GTC	G[T>A]C	0.00055241	0.000293862	0.005615432	0.0052	0.004021596	0.0028	0
T>A	GTG	G[T>A]G	0.001200229	8.87213E-05	0.008070136	0.0133	0.006814352	0.0006	0.0006
T>A	GTT	G[T>A]T	0.002107137	0.000215755	0.008679122	0.0045	0.005101033	0.0021	0.001
T>C	GTA	G[T>C]A	0.011247835	4.67385E-06	0.006850056	0.0061	0.016294983	0.0122	0.0002
T>C	GTC	G[T>C]C	0.006999724	0.000186066	0.006260749	0.0016	0.009574561	0.0059	0.0001
T>C	GTG	G[T>C]G	0.004977593	4.95044E-07	0.006098763	0.0042	0.014103929	0.0115	0.0003
T>C	GTT	G[T>C]T	0.010667406	0.000578598	0.007509344	0.0024	0.015666875	0.0042	0.0081
T>G	GTA	G[T>G]A	9.9045E-05	9.55524E-05	0.004144488	0	0.001627665	0	0
T>G	GTC	G[T>G]C	0.000202366	4.70024E-05	0.004501985	0	0.000327735	0.0016	0
T>G	GTG	G[T>G]G	0.001188353	0.000109926	0.016391453	0.0018	0.00594888	0.001	0.0017
T>G	GTT	G[T>G]T	0.000800723	8.64772E-05	0.007067237	0.0002	0.003307467	0.0035	0.0009
C>A	TCA	T[C>A]A	0.012250064	0.015127428	0.011653225	0.033	0.014774016	0.0017	0.001
C>A	TCC	T[C>A]C	0.011162229	0.006532492	0.016606775	0.0538	0.012043465	0.0029	0.002
C>A	TCG	T[C>A]G	0.002275496	0.001656455	0.001357239	0.0104	0.003902362	0.0011	0.0002
C>A	TCT	T[C>A]T	0.015259102	0.012394611	0.016328076	0.037	0.018243396	0.0058	0.0013
C>G	TCA	T[C>G]A	0.001874853	0.037241853	0.016041405	0.0032	0.002681057	0	0.0002
C>G	TCC	T[C>G]C	0.002067419	1.94134E-05	0.02014992	0.0105	0.007924048	0.0002	0.001
C>G	TCG	T[C>G]G	0.000304897	0.001625465	0.002527911	0.0031	0.001319076	0	0.0003
C>G	TCT	T[C>G]T	0.003151574	0.0668799	0.032673641	0.005	0.006644596	0.0001	0.0007
C>T	TCA	T[C>T]A	0.0144921	0.4199414	0.008880209	0.0035	0.01099756	0.0074	0.1202
C>T	TCC	T[C>T]C	0.017680775	0.081972496	0.013529573	0.007	0.020644965	0.0067	0.2887
C>T	TCG	T[C>T]G	0.076002222	0.047720186	0.001705409	0.0011	0.00753449	0.0391	0.0992
C>T	TCT	T[C>T]T	0.013761704	0.228674918	0.010304417	0.0077	0.011787462	0.0047	0.0844
T>A	TTA	T[T>A]A	0.005600155	8.07525E-05	0.007132681	0.0045	0.009205637	0.0002	0.001
T>A	TTC	T[T>A]C	0.001999079	4.8029E-06	0.009102798	0.0046	0.006835344	0.0008	0.0015
T>A	TTG	T[T>A]G	0.001090066	6.6605E-05	0.006565863	0.0082	0.007144209	0	0.001
T>A	TTT	T[T>A]T	0.003981023	0.000276316	0.014712135	0.0045	0.01024085	0.0007	0.005
T>C	TTA	T[T>C]A	0.008073616	0.000101932	0.009115495	0.0028	0.017059641	0.0059	0.0023
T>C	TTC	T[T>C]C	0.004857381	0.000470344	0.010953791	0.0016	0.014195709	0.0035	0.0018
T>C	TTG	T[T>C]G	0.008325454	0.000192354	0.006113033	0.0036	0.012596502	0.0106	0.0019
T>C	TTT	T[T>C]T	0.006257106	0.00058533	0.010774336	0.0022	0.017375139	0.0029	0.0024
T>G	TTA	T[T>G]A	0.001397554	7.1737E-05	0.005427184	0	0.005202874	0.0009	0
T>G	TTC	T[T>G]C	0.001291737	1.42815E-05	0.00616025	0.0003	0.005131608	0.0019	0.001
T>G	TTG	T[T>G]G	0.002031077	0.000206615	0.011076526	0.003	0.006055254	0.0011	0.001
T>G	TTT	T[T>G]T	0.004030128	2.35982E-05	0.013000984	0.0011	0.013369936	0.0072	0.0014